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KMID : 0043320070300101205
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Archives of Pharmacal Research
2007 Volume.30 No. 10 p.1205 ~ p.1209
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Alternative and Improved Syntheses of Highly Potent and Selective A3 Adenosine Receptor Agonists, Cl-IB-MECA and Thio-Cl-IB-MECA
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Hou Xiyan
Lee Hyuk-Woo
Tosh Dilip K.
Zhao Long Xuan
Jeong Lak-Shin
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Abstract
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Improved syntheses of potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA were accomplished from cheap stating material, D-ribose. New synthetic methods were found to be superior to old methods from the viewpoint of use of cheap starting material, number of steps, and overall yields
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KEYWORD
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Cl-IB-MECA, Thio-Cl-IB-MECA, Adenosine receptor, Improved synthses
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